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Dimethyl Isosorbide (DMI)

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Dimethyl Isosorbide 
CAS No.: 5306-85-4

Dimethyl Isosorbide (DMI) is a high purity solvent and carrier which offers a safe, effective delivery enhancement mechanism for active ingredients in personal care products. Sunless tanners, facial and eye-zone treatments, skin serums, anti-acne formulations and make-up removers are just some of the products whose performance can be improved with the use of Dimethyl Isosorbide (DMI) in formulation. In addition to improving performance, its use as an epidermal penetration enhancer may allow formulators to reduce the amount of actives required to achieve effects, resulting in reduced formulation costs, and lower skin irritation with aggressive active ingredients.

Dimethyl Isosorbide (DMI) offers:

  • Enhanced penetration of actives to the epidermis, reaching areas that would otherwise go untreated
  • Improved shelf stability of active ingredients, including actives susceptible to hydrolysis and transesterification
  • Miscibility in water, most organic solvents and non-ionic surfactants
  • The ability to transport water soluble actives into skin without recrystallization of the active ingredient

Dimethyl Isosorbide is soluble in a variety of ingredients including water, cottonseed oil, isopropanol, isopropyl myristate, propylene glycol, polysorbate 20, and polysorbate 80. It is insoluble in hydrogenated castor oil, lanolin, mineral oils or silicone oil (dimethicone).

Suggested Usage: 1 - 10%
Appearance: Clear oily liquid
Solubility: Soluble in water (see above)

INCI: Dimethyl Isosorbide

Caution: Do not directly apply onto your skin.
This product should be added to a formulation at the recommended usage rate.

Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.

Here you will find Material Safety Data Sheets (MSDS) and Technical Data Sheets. The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Technical Data
Dimethyl Isosorbide (DMI) Fact Sheet


Material Safety Data Sheet (MSDS)

Dimethyl Isosorbide (DMI) MSDS


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