DECORINYL™
CAS: Mixture

Decorinyl™ is a synthesized tetrapeptide which mimics the sequences of decorin that bind to collagen fibrils. It has been shown to regulate fibrillogenesis and control fibril growth, improving firmness and elasticity of the skin, ensuring uniformity of fibril diameter and spacing of collagen fibrils. In effect, it replaces the non-functional decorin encountered as the skin ages, and also sustains a superior moisture profile.

Fibrillogenesis is an essential process in tissue formation, but must be controlled and regulated in order to avoid excessive bundle-like aggregation of collagen. The fibrillogenesis control is the role of decorin, a small leucine-rich proteoglycan, which is associated with collagen fibrils at specific binding sites in the protein core, controlling fibril dimensions, the uniformity of their diameter and their regular spacing.

Aging skin contains a truncated form of decorin, which lacks binding regions with collagen fibrils, producing a negative effect on the elasticity on the skin. Decorinyl™ is a mimic peptide of these binding sequences that has been proven to regulate fibrillogenesis, control collagen fibril diameter and increase skin suppleness.

Decorinyl™ has been incorporated into a liposomal system for enhanced penetration, stability and efficacy. It is recommended for cosmetic formulations designed for mature skin where an improvement of suppleness and strength of skin is desired. It may be used in emulsions, gels and other formulations.

Incorporation: Decorinyl™ can be incorporated in the final stage of the manufacturing process, when the temperature has reached 35 - 40°C (95 - 104°F). Care should be taken not to exceed 50°C (122°F)

Appearance: Off white to amber liquid suspension
pH: 5.0 - 6.5
Tripeptide-10 Citrulline Content: 0.2%
Solubility: Water soluble
Preservative: 0.9% Phenoxyethanol

Storage: Keep in a cool (between 15 and 25°C /59 and 77°F), dark and clean place. In order to avoid secondary microbial contamination, following opening, containers should be handled with special care. If stored as recommended, Decorinyl™ remains stable for at least 12 months.

Recommended Usage Rate: 5%

INCI: Water (and) Lecithin (and) Tripeptide-10 Citrulline (and) Carbomer (and) Triethanolamine (and) Caprylyl Glycol

This product should be added to a formulation at the recommended usage rate.

Disclaimer
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.