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 Cosmoperine, also known as tetrahydropiperine (THP), is derived from piperine, the active principle of black peppercorns (Piper nigrum) which acts as a penetration enhancer when added to water soluble ingredients. It works by enhancing the bioavailability of nutrients, including vitamins, minerals, coenzymes, and nutraceutical herbal extracts. An increase in topical permeation was shown when combining Cosmoperine with products like Green Tea extract; an antioxidant rich in polyphenols, Coleus Forskohlli Extract; a skin conditioning agent and Tetrahydrocurcumin; derived from Curcuminoids as extracted from Tumeric Root, acting as a potent antioxidant. One study showed an enhanced absorbtion of 30% in Vitamin C and Beta Carotene.

While at present there is insufficient experimental data to determine the actual mechanism of THP’s bioenhancing properties, it is postulated that THP may operate by increasing either the membrane’s fluidity and/or the affinity of the nutrient to the cell membrane. THP is also a lipophilic compound and may therefore increase solubilization of the intracellular lipid moiety in the skin, making it more permeable to the applied nutrient.

Recommended Usage Rate: 0.1-1.0%

Appearance: White powder
Solubility: Soluble in Dimethyl Isosorbide, Ethoxydiglycol and ethanol, partially soluble in propylene glycol, insoluble in water and glycerin
Storage: Store in cool, dry place in original container away from light and moisture
Shelf life: Three years, properly stored.

INCI: Tetrahydropiperine

Cosmoperine® is a patented product of Sabinsa Corporation.

Here you will find Material Safety Data Sheets (MSDS) and Technical Data Sheets. The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Technical Data

Cosmoperine as Enhancer of Nutrient and Drug Bioavailability


Material Safety Data Sheet (MSDS)

Cosmoperine MSDS

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