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Biguanide 20

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Biguanide 20 
CAS No. 27083-27-8

PLEASE READ:  Biguanide 20 has been reclassified as a Class 9 Hazardous Material, because it is an Environmentally Hazardous Substance (harmful to aquatic life).  However, it is not classified as such for DOMESTIC USA shipping, per DOT, so we are able to ship it domestically.  We are unable to ship this internationally without Hazardous Material shipping packaging and documentation.  Do not order this if you are shipping to a US Parcel Forwarder for export!

Biguanide 20, also known as Polyaminopropyl Biguanide (PABG), is a broad spectrum, fast acting bactericide. It is provided by the manufacturer as a 20% solution in water.  A 20% aqueous solution of poly(hexamethylenebiguanide) hydrochloride, also known as PHMB, Polyaminopropyl Biguanide, used at an appropriate usage level (of 0.2 - 1.5%) is an effective preservative for make-up removers, moisturizing toners, facial cleansers, wet wipes and also offers antibacterial and deodorant properties. Originally formulated for the contact lens industry, it is also typically used in baby wipes. It is gentle in-use, with low eye and skin irritancy and low oral toxicity.

Biguanide 20 is an effective non-formaldehyde, non-paraben preservative with no VOCs (Volatile Organic Compounds) which is heat and UV stable. It is effective over a broad pH range (4-10), but most effective at a pH of 6.0 or less. As it is cationic, it is compatible with cationic, amphoteric and non-ionic surfactants. It is incompatible with strongly anionic systems.

Biguanide 20 is incompatible with natural liquid soaps and beeswax/borax emulsions. It is more compatible with cationic emulsifiers like Lotioncrafter BTMS. Biguanide 20 is not compatible with Xanthan Gum.

Biguanide 20 is heat stable to at least 80°C (176°F) and can be added pre or post emulsification. For complex formulations, consider combining with another preservative for a broader spectrum of activity or potassium sorbate for increased antifungal/mold protection.**

Recommended usage level: 0.2 - 1.5%.
Appearance: Clear to slightly pale yellow, slightly opalescent liquid.
pH: 5.0 - 5.5
Specific Gravity: 1.04
Solubility: Soluble in water. Miscible with ethanol, glycerin, and propylene glycol.

INCI: Polyaminopropyl Biguanide

Click here to access "Cosmocil CQ Antimicrobial - Effective Use in Personal Hygiene Wipes" by Dr. Terry Yeates, Avecia Protection & Hygiene, developers of Cosmocil CQ. Of particular interest is Table 1 citing how Polyaminopropyl Biguanide may be co-formulated with additional antimicrobial agents to provide complementary and wider spectrum of activity (including the use of potassium sorbate, among others).


Here you will find Material Safety Data Sheets (MSDS) and Technical Data Sheets. The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Technical Data

Material Safety Data Sheet (MSDS)

Biguanide 20 MSDS


Lotioncrafter formulas in which this ingredient appears are listed below. Formulas are used as a means to provide basic formulating information and guidance in the use of ingredients Lotioncrafter supplies. Formulations are provided in percentages, grams and ounces. Most create a batch size of 1000g (33 ounces). Because percentages are provided, they can be sized up or down with ease.

The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Exfoliating Body Conditioner
Simple & Luxurious Hair Conditioner

By accessing this formulation you acknowledge that it is your responsibility to ensure formulation integrity and freedom to practice and that the information herein is provided with no warranties express or implied. Ensuring suitability and stability is your responsibility in every respect and should include doing appropriate formula stability and preservative efficacy testing as well as appropriate patent search and analysis.

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It's Columbus Day on Monday, a Federal holiday, and post offices will be closed. Lotioncrafter's office will be open as usual, but only UPS will be shipping on Monday. We will resume US Mail shipping on Tuesday. Happy Thanksgiving to all our Canadian customers!

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