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Loss of skin firmness is one very visible sign of aging. SYN®-HYCAN helps to fight sagging skin by boosting hyaluronan content and increasing the expression of decorin and lumican.

Hyaluronan (HA) plays an important role in the skin. This glucosaminoglycan (GAG) consists of a long sugar chain that can bind up to 1,000 times its weight in water. The excellent moisture-holding property leads to a gel-like framework for collagen, elastin and skin cells. Also important is its ability to act as a filler, which helps provide the skin with mechanical cushioning. SYN®-HYCAN boosts hyaluronan production and allows needle-free HA-based face contour remodeling.

Decorin and lumican are two important proteoglycans of the dermis. Their protein part binds to a collagen fibril while the GAG part acts as a spacer between the fibrils. The result is the formation of thinner collagen fibrils with increased quality and strength.

Both activities of SYN®-HYCAN work nicely together: Fresh hyaluronan and stronger collagen fibrils result in a visible remodeling effect and a firmer skin.

SYN®-HYCAN is a tripeptide which helps to fight skin sagging by boosting hyaluronan production and improving collagen fibrillogenisis. SYN®-HYCAN has a firming and remodeling effect by stimulation of GAG (glycosaminoglycan) biosynthesis. SYN®-HYCAN increases Decorin and Lumican levels for better collagen fibers.

SYN®-HYCAN is a glycerin-based aqueous solution that is both preservative and PEG-free.

Cosmetic Applications:

  • Firming body treatment
  • Remodelling face contour cream
  • Anti-sagging treatment
  • Moisturizing (from within) lotions
  • Anti-aging (filling wrinkles from within) solutions
  • Anti-cellulite gels

Incorporation: Syn-Hycan can be processed either warm (max. 80°C/176°F) or cold, and is incorporated into the aqueous phase of a cosmetic formulation or at the end of the process. Optimal pH-range for formulating with Syn-Hycan ranges from 3.0 - 5.5.

Recommended Usage Rate:  2.5%
Appearance:  Colorless, transparent liquid
Preservative:  Preservative free
Storage:  Should be stored in the original sealed containers protected from light in a clean place at a temperature between 2 and 8°C (35° - 46°F). After opening the container add Nitrogen or Argon (or Lotioncrafter OxBlox) to protect the leftover in the original container, protected from light and in a clean place. May be refrigerated as before.

INCI: Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate (and) Magnesium Chloride (and) Glycerin

This product should be added to a formulation at the recommended usage rate.

Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.

Here you will find Material Safety Data Sheets (MSDS) and Technical Data Sheets. The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Technical Data

Syn-Hycan Fact Sheet
Syn-Hycan Formulation Guidelines
Material Safety Data Sheet (MSDS)

Syn-Hycan  MSDS


Lotioncrafter formulas in which this ingredient appears are listed below. Formulas are used as a means to provide basic formulating information and guidance in the use of ingredients Lotioncrafter supplies. Formulations are provided in percentages, grams and ounces. Most create a batch size of 1000g (33 ounces). Because percentages are provided, they can be sized up or down with ease.

The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Antiaging Facial Moisturizer for Mature Skin

By accessing this formulation you acknowledge that it is your responsibility to ensure formulation integrity and freedom to practice and that the information herein is provided with no warranties express or implied. Ensuring suitability and stability is your responsibility in every respect and should include doing appropriate formula stability and preservative efficacy testing as well as appropriate patent search and analysis.

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