Metabiotics™ Resveratrol

Remarkable advances in anti-aging applications for skin resilience, including reductions in fine lines and improvement in skin tone, are being seen with the addition of Metabiotics™ Resveratrol to cosmetic formulations. Produced through fermentation of the small molecule, resveratrol, with the microorganism, Pichia pastoris, this innovative biotechnological ingredient is designed for use in anti-aging skin creams and related products.

Pichia pastoris, the microorganism used in the production of Metabiotics™ Resveratrol, was chosen chiefly due to its long history of use in the pharmaceutical industry where it is considered GRAS or generally recognized as safe by the FDA. Only recently has it been explored for its use in personal care applications. Pichia pastoris, like others of the Saccharomycetase genus to which it belongs, has the distinctive ability to express bio-actives that are capable of unique benefits, without application of human cell lines. Uniquely, it also has an affinity for lipid based compounds, therefore acting as a model organism for biofermentation of oil soluble or insoluble actives like resveratrol, which has presented formulating challenges due to its water solubility and stability limitations.

Collagen IV and anti-inflammatory synthesis activity is afforded through the complete metabolization of the resveratrol in the biofermentation process, targeting micro-inflammation and maintaining the structural integrity of skin cells through the dermal epidermal junction (DEJ). An ideal active to incorporate in cosmetic formulations designed to ameliorate the visible signs of aging, Metabiotics™ Resveratrol promotes firming and helps rebuild DEJ structural integrity.

In vitro studies were performed to determine the inhibitory benefits of Metabiotics™ Resveratrol on a full thickness tissue model to reduce expression of the anti-inflammatory enzyme cyclooxygenase 1 [COX1] along with its ability to promote the synthesis of Collagen IVA on the same tissue model. The results, in both cases, confirm with statistical significance that either a 1% or 2% treatment of Metabiotics™ Resveratrol reduces the levels of the COX1 enzyme and increases the amount of COLL IVA synthesis. In vivo, an anti-aging study has confirmed a reduction in fine lines and wrinkles following a 28-day application, as well as firming and lifting of the skin to reduce notable sagging that was present prior to treatment.

Key attributes include:

• Anti-Wrinkle
• Targets Expression Wrinkles
• Enhanced Skin Tone
• Skin Firming and Smoothing
• Collagen Synthesis
• Promoting Extra Cellular Matrix
• Non-Animal Derived
• Anti-Inflammatory

Incorporation: Add at the end of the emulsion, at cool down, below 40C (104F).

Recommended Usage Rate: 1-5%
Appearance: Light yellowish liquid with characteristic odor
pH: 5.5
Solubility: Soluble in water
Preservative: Phenoxyethanol at 1%

INCI: Pichia/Resveratrol Ferment Extract

This product should be added to a formulation at the recommended usage rate.

Metabiotics^TM Resveratrol is a trademark of Arch Personal Care Products.

Disclaimer
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.