ELHIBIN®
CAS: 9010-10-0

ELHIBIN® is a biological, plant-based proteinase inhibitor system sourced from Soybean protein. ELHIBIN® is isolated and purified by Pentapharm Ltd. as a highly active yellowish aqueous solution by means of a worldwide patented and controlled multistep down-stream procedure performed in accordance with GMP. ELHIBIN® inhibits human leukocyte elastase, a proteinase that plays an essential role in irritation processes and accelerated skin aging.

Various biochemical and biophysical systems help to maintain the integrity of the skin via complex physiological processes with well-defined interactions between cells and proteolytic reaction cascades. Proteinases are involved in practically every aspect of life. Disturbance of the sensitive balance between proteinase and proteinase inhibitors, however, may lead to uncontrolled reactions. Proteinase activity is therefore carefully regulated by specific inhibitors.

Any irritation caused by either UV-exposure or by environmental stress directly leads to the accumulation and stimulation of white blood cells, the so-called leukocytes. Stimulated leukocytes release large amounts of the proteinase elastase to their membrane surface and into their surrounding area. When uncontrolled, elastase is potentially the most destructive proteinase present in the body; it can attack all major connective tissue proteins. All uncontrolled elastase activity may thus endanger the integrity of the skin. Massively increased elastase activity is found in skin lesions due to allergic contact dermatitis, atopic dermatitis and psoriasis. However, elevated levels of elastase can also be found on the surface of dry skin and on skin irritated by UV exposure and environmental stress. For this reason ELHIBIN® should be considered in the creation of new concepts for moisturizers, sun protection and after-sun products.

Incorporation: ELHIBIN® can be processed either warm (< 60°C/140°F) or cold, and is incorporated into the aqueous phase of a cosmetic formulation. ELHIBIN® is stable in the pH-range of 5.5 to 8. In formulations, ELHIBIN® is compatible with ethanol at concentrations of up to 20%.
Recommended Usage Rate: 3-7%
Appearance: Clear to slightly opalescent, yellowish liquid
pH: 5.2 - 6.0
Preservative: Phenonip at 0.65 - 0.85%
Storage: Keep in a cool (between 15 and 25°C /59 and 77°F), dark and clean place. In order to avoid secondary microbial contamination, following opening, containers should be handled with special care. If stored as recommended, ELHIBIN® remains stable for at least 3 years.

INCI: Glycine Soja (Soybean) Protein

This product should be added to a formulation at the recommended usage rate.

Disclaimer
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.