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Gladback™ is a purified and standardized fraction of Poria cocos for mature and/or menopause skins. It is a multi-functional active ingredient which increases skin thickness, radiance and microcirculation, and it also reduces the appearance of wrinkles typical of aging.

Poria cocos is a well-known fungus in Asian traditional medicine where it is used as a purifying, antioxidant and softening agent.  In GladbackTM, the part used st the sclerocia (mycelium), which is rich in polysacchrides (pachyman) and triterpenes.

Target Dermal Structures of GladbackTM

  • Hyaluronic acid: essential glycosaminoglycan of the dermal and epidermal extracellular matrix, which acts directly on tissue cohesion and repair.
  • CD44: trans-membrane glycoprotein which acts as the main receptor of hyaluronic acid and maintains its homeostasis. The interaction between the hyaluronic acid and this receptor facilitates cellular differentiation and strengthens tissue union.
    • During aging and menopause the expression of the CD44 receptor and hyaluronic acid diminishes, leading to a reduced skin thickness, firmness and cell renewal.
    • Gladback™ increases the expression of this receptor, improving the hyaluronic acid binding
      in the epidermis and dermis.
  • Collagen IV: maintains the skin mechanical stability as it is a key element of the dermal-epidermal junction.
    • Age diminishes collagen and menopause accentuates even more this loss.
      Gladback™ boosts the expression of collagen IV and strengthens skin stability.
  • SPRR: family of small proteins rich in prolin, located in the dense envelope of the corneocytes (epidermis).
    • Due to aging and menopause these proteins become over expressed, and this causes important skin imbalances.
    • Gladback™ reduces the expression of SPRR and improves the appearance of mature skin.

Gladback™ rolls back the effects of aging in skin thickness, microcirculation, radiance and firmness. The result is a younger and more radiant skin.

Cosmetic Applications

  • Facial and corporal care for mature skins
  • Anti-aging global lines
  • Make up with treatment

Incorporation: Gladback should be processed below 40°C (104°F).

Recommended Usage Rate: 3-6%, safe up to 100%

Appearance: Light grey-brown to grey-brown transparent liquid
Solubility: Water Soluble
pH as supplied: 4.5 - 5.5
Raw Material Preserved with: Gluconolactone, Sodium Benzoate, Calcium Gluconate, Potassium Sorbate, Sodium Benzoate
Storage: Clean, cool room temperature storage, out of direct sunlight.

INCI: Water (and) Glycerin (and) Poria Cocos Polysaccharide

Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.

Here you will find Material Safety Data Sheets (MSDS) and Technical Data Sheets. The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.


Technical Data
Gladback Fact Sheet
Gladback Technical Literature
Material Safety Data Sheet (MSDS)

Gladback MSDS

Lotioncrafter formulas in which this ingredient appears are listed below. Formulas are used as a means to provide basic formulating information and guidance in the use of ingredients Lotioncrafter supplies. Formulations are provided in percentages, grams and ounces. Most create a batch size of 1000g (33 ounces). Because percentages are provided, they can be sized up or down with ease.

The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Antiaging Facial Moisturizer for Mature Skin

By accessing this formulation you acknowledge that it is your responsibility to ensure formulation integrity and freedom to practice and that the information herein is provided with no warranties express or implied. Ensuring suitability and stability is your responsibility in every respect and should include doing appropriate formula stability and preservative efficacy testing as well as appropriate patent search and analysis.

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